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CRTH2-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CRTH2-IN-1图片
CAS NO:926661-54-3
包装:5 mg
市场价:7000元

产品名称
Ramatroban analog
产品介绍

产品描述

CRTH2-IN-1 is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist, a Ramatroban analog, with an IC50 of 6 nM in the human DP2 binding assay.

体外活性

CRTH2-IN-1 (Ramatroban analog) is a new type of prostaglandin D2 receptor DP2 (CRTH2) antagonist with IC50 of 7 nM in human whole blood eosinophil deformation assay (hESC). It has efficacy in a mouse model of allergic rhinitis. Using 3H-PGD2 and human platelet membrane for human prostaglandin D1 receptor (hDP1) binding. Human thromboxane receptor (hTP) binding was performed using human platelet membrane and 3H-SQ-29,548. HIP / 293 membrane and 3Hiloprost were used for human prostacyclin receptor (hIP) binding. CRTH2-IN-1 inhibits hDP1 binding with IC50 of 1 μM. CRTH2-IN-1 inhibits the combination of hTP and hIP with IC50 greater than 100 μM. CRTH2-IN-1 inhibits human CYP subtypes CYP3A4, CYP 2C9 and CYP2D6 with IC50 of 7, 5 and>30 μM, respectively.

Cas No.

926661-54-3

分子式

C21H21FN2O4S

分子量

416.47

别名

Ramatroban analog;CRTH2-IN-1

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years