Glufosinate ammonium 是谷氨酸的一种膦酸类似物，是一种除草剂，在植物细胞中转化为 PT (L-phosphinothricin) 。Glufosinate ammonium显示出神经毒性作用。

Glufosinate ammonium is a phosphinic acid analogue of glutamic acid and is an herbicide. Glufosinate ammonium is converted by plant cells into PT (L-phosphinothricin). Glufosinate ammonium has neurotoxic activity.

Glufosinate ammonium impairs ependymal cell capability to synthetize cilia. Glufosinate ammonium (1-100 μM; 12DIV) obviously reduces Celsr2 gene expression at 100 μM. Glufosinate ammonium (1-100 μM; 12DIV) disrupts cell-cell adhesion in differentiated V-SVZ neural stem cells (NSCs) [2].

Glufosinate ammonium (10-250 mg/kg; gavage; Daily; on days 6-15 of gestation) shows maternal toxicity in the groups given 50 or 250 mg/kg in Wistar rats. In male and female rats, the Elimination of Glufosinate ammonium (oral intubation) in the blood takes place with a half-life of fewer than 4 hours [3].

77182-82-2

C5H15N2O4P

198.16

Glufosinate ammonium

H2O:250 mg/mL (1261.61 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years