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Bemegride(Bemegrid)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bemegride(Bemegrid)图片
CAS NO:64-65-3
规格:≥98%
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议
1g电议
2g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)155.19
FormulaC8H13NO2
CAS No.64-65-3
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 31 mg/mL (199.8 mM)
Water:<1 mg/mL
Ethanol: 31 mg/mL (199.8 mM)
Other info

Chemical Name: 2,6-Piperidinedione, 4-ethyl-4-methyl-

InChi Key: ORRZGUBHBVWWOP-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H13NO2/c1-3-8(2)4-6(10)9-7(11)5-8/h3-5H2,1-2H3,(H,9,10,11)

SMILES Code: O=C(CC(C)(CC)C1)NC1=O

Synonyms

Antibarbi; Agipnon; Ahypnon; Bemegrid; Eukraton; Malysol; Mikedimide; Zentraleptin

实验参考方法
In Vitro

In vitro activity: Bemegride has an antagonistic action on the GABAA receptor, suppressing both GABA- and pentobarbitone-evoked whole-cell currents to similar extents.

In VivoLong-term oral administration to the rat of barbitone, alone or together with the analeptics bemegride or pentylenetetrazol, show that the intensity of the withdrawal syndrome generally parallels the degree of associated CNS depression.
Animal modelRats
Formulation & DosageOra
References

Exp Physiol. 1990 Mar;75(2):199-209; Farmaco Sci. 1986 Jan;41(1):3-22.