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Pafuramidine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pafuramidine图片
CAS NO:186953-56-0
包装与价格:
包装价格(元)
50 mg电议
100 mg电议

产品名称
DB289
产品介绍

产品描述

Pafuramidine is an orally bioavailable prodrug of furamidine. It has activity against Pneumocystis pneumonia (IC50 value: 4.5 nM)

体外活性

The results of this investigation suggest that DB75 inhibits mitochondrial function. Yeast cells relying upon mitochondrial metabolism for energy production are especially sensitive to DB75 [1].

体内活性

DB289, a novel orally active prodrug of DB75, is undergoing phase IIb clinical trials for early-stage human African trypanosomiasis, Pneumocystis jiroveci carinii pneumonia, and malaria [1]. Clearance of DB289 approximated the liver plasma flow and its large volume of distribution was consistent with extensive tissue binding. Plasma protein binding of DB289 was 97 to 99% in four animal species and humans, but that of DB75 was noticeably less and more species- and concentration-dependent [2]. Despite excellent oral activity against early-stage sleeping sickness, oral administration of DB289 exhibited limited efficacy in mouse models of late-stage disease [3].

Cas No.

186953-56-0

分子式

C20H20N4O3

分子量

364.4

别名

DB289;Pafuramidine

储存和溶解度

DMSO:33.33 mg/mL (91.47 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years