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Heat Shock Protein Inhibitor II
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Heat Shock Protein Inhibitor II图片
CAS NO:1859-42-3
包装:100 mg
市场价:9111元

产品介绍

产品描述

Heat shock protein (Hsp) inhibitor II is the active form of Hsp inhibitor I and a benzylidene lactam compound that prevents the synthesis of inducible Hsps, such as Hsp105, Hsp72, and Hsp40. Hsp inhibitor II decreases Hsp72 synthesis in vivo and reduces thermotolerance of tumors in SCC VII tumor-containing mice. At 100 μM, it inhibits the development of thermotolerance in COLO 320 DM cells. Inhibition of Hsp70 with Hsp inhibitor II in combination with amphotericin B increases susceptibility of AmB-susceptible (MICs = 0.058 versus 0.27 μg/ml for combined and AmB alone, respectively) and AmB-resistant (MICs = 21.33 versus >32 μg/ml for combined and AmB alone, respectively) strains of A. fumigatus.

Cas No.

1859-42-3

分子式

C12H11NO3

分子量

217.22

别名

Heat Shock Protein Inhibitor II

储存和溶解度

DMSO:10 mg/mL
DMF:10 mg/mL
DMSO:PBS (pH 7.2)(1:5):0.1 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years