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cDPCP
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:106343-59-3
包装:10 mg
市场价:8034元

产品介绍

产品描述

cDPCP is a platinum-containing DNA-crosslinking agent.1Unlike cisplatin or oxaliplatin , cDPCP forms monofunctional DNA adducts. It is transported into cells by organic cation transporter 1 (OCT1) and OCT2, inhibiting proliferation of MDCK cells expressing the human transporters with IC50values of 8.1 and 1.5 μM, respectively. cDPCP inhibits RNA polymerase II-mediated transcription in a reporter assay using HeLa cells. It increases survival in murine S180 sarcoma and P388 leukemia models when administered at doses of 40 and 80 mg/kg, respectively.2

Cas No.

106343-59-3

分子式

C5H11Cl2N3Pt

分子量

379.15

别名

cDPCP

储存和溶解度

H2O:Slightly soluble
DMSO:Slightly soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years