4-oxo Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells and carboplatin-resistant A2780 (A2780/CP70) cells (IC50s = 7.3 and<1 μM, respectively) and is 4.4-fold selective for A2780 cells over non-cancerous ARPE19 cells.

6850-30-2

C28H36O6

468.58

4-oxo Withaferin A

DMSO:5 mg/mL
DMF:5 mg/mL
DMSO:PBS (pH 7.2) (1:1):0.5 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years