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Neuromedin U-25(human)(trifluoroacetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Neuromedin U-25(human)(trifluoroacetate salt)图片
包装与价格:
包装价格(元)
1 mg电议
5 mg电议

产品名称
Neuromedin U-25 (human) (trifluoroacetate salt)
产品介绍

产品描述

Neuromedin U (NMU) is a neuropeptide first demonstrated to drive smooth muscle contraction.1Translated as a 174 amino acid propeptide, NMU is cleaved to different lengths in different animals. It has diverse receptor-mediated rolesin vivo, as it regulates feeding, vasoconstriction, nociception, and bone remodeling and contributes to obesity, cancer and septic shock.2,2NMU-25 is the active form of NMU in humans. It binds with high affinity to receptors on human left ventricle and coronary artery (KDs = 0.26 and 0.11 nM, respectively), eliciting endothelium-independent vasoconstriction.3NMU-25 also suppresses glucose-stimulated insulin secretion in human islets, and this effect is lost in NMU R165W mutants, resulting in early-onset obesity.4

别名

Neuromedin U-25 (human) (trifluoroacetate salt)

储存和溶解度

DMSO:1 mg/mL
DMF:5 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years