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GM 1489
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GM 1489图片
CAS NO:171347-75-4
包装:25 mg
市场价:14281元

产品介绍

产品描述

GM 1489 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with Ki values of 0.002, 0.1, 0.5, 0.2, and 20 μM for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively. It reduces 5-aza-2'-deoxycytidine-induced increases in MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, and MMP-14 expression as well as cell invasion in AsPC-1, BxPC-3, Hs766T, MiaPaCa2, and PANC-1 cancer cells. Topical administration of GM 1489 (100 μg) inhibits increases in ear thickness and epidermal hyperplasia induced by phorbol 12-myristate 13-acetate and phorbol dibutyrate (PdiBu) in mice.

Cas No.

171347-75-4

分子式

C27H33N3O4

分子量

463.578

别名

GM 1489

储存和溶解度

DMF:50 mg/mL
Ethanol:20 mg/mL
DMSO:50 mg/mL
PBS (pH 7.2):0.2 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years