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Forodesine hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Forodesine hydrochloride图片
CAS NO:284490-13-7
包装:200 mg
市场价:10254元

产品名称
Immucillin-H hydrochloride
BCX-1777 hydrochloride
产品介绍

产品描述

Forodesine hydrochloride is a potent human lymphocyte proliferation inhibitor. Forodesine hydrochloride could induce apoptosis in leukemic cells by increasing the dGTP levels. Forodesine hydrochloride (BCX-1777 hydrochloride) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP.

体外活性

Forodesine (BCX-1777), in the presence of 2'-deoxyguanosine (dGuo, 3-10 μM), inhibits human lymphocyte proliferation activated by various agents such as interleukin-2 (IL-2), mixed lymphocyte reaction (MLR) and phytohemagglutinin (PHA) (IC50 values

体内活性

n the human peripheral blood lymphocyte severe combined immunodeficiency (hu-PBL-SCID) mouse model, Forodesine is effective in prolonging the life span 2-fold or more.Forodesine (BCX-1777) has excellent oral bioavailability (63%) in mice.?At a single dose of 10 mg/kg in mice, Forodesine elevates dGuo to approximately 5 μM.

Cas No.

284490-13-7

分子式

C11H15ClN4O4

分子量

302.71

别名

Immucillin-H hydrochloride;BCX-1777 hydrochloride;Forodesine hydrochloride

储存和溶解度

H2O:16.67 mg/mL (55.07 mM),Need ultrasonic
DMSO:16.67 mg/mL (55.07 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years