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RJW100
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
RJW100图片
CAS NO:1276664-20-0
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
100 mg电议
500 mg电议

产品介绍
RJW100 是一种有效的肝受体同源物 1 (LRH-1,NR5A2) 和类固醇生成因子-1 (SF-1,NR5A1) 激动剂,pEC50 分别为 6.6 和 7.5。RJW100 还可有效激活 miR-200c (miRNA-200c, microRNA-200c) 启动子。

产品描述

RJW100 is a potent liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1) agonist with pEC 50 s of 6.6 and 7.5, respectively. RJW100 also causes strong activation of the miR-200c (miRNA-200c, microRNA-200c) promoter.

体外活性

RJW100 (compound 24-exo) treatment induces a significant dose-dependent increase in small/short heterodimer partner (SHP) transcripts beginning at 5 μM. RJW100 (compound 24-exo) clearly displaces the bound PIP2 phospholipid from SF-1 almost completely at 1 μM. Using hLRH-1 LBD alone that had not been complexed with any phospholipids, the result shows a clear dose-dependent shift in hLRH-1 LBD (ligand binding domain) native PAGE migration upon RJW100 (compound 24-exo; 0-100 μM) binding[1]. RJW100 causes strong activation of the miR-200c promoter and exhibits strong ability to downregulate ZEB1 and ZEB2 proteins[2].

Cas No.

1276664-20-0

分子式

C28H34O

分子量

386.57

别名

RJW100

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years