Topoisomerase II inhibitor 6 (Compound 5) 是一种色胺酮衍生物，是一种有效的、选择性的topoisomerase II抑制剂。Topoisomerase II inhibitor 6 对不同的肿瘤细胞系表现出抗增殖活性。Topoisomerase II inhibitor 6 在 G2 期阻断 CCRF-CEM 的细胞周期并诱导 DNA DSB。Topoisomerase II inhibitor 6 具有研究癌症疾病的潜力。

Topoisomerase II inhibitor 6 (Compound 5), a tryptanthrin derivative, is a potent and selective inhibitor of topoisomerase II. Topoisomerase II inhibitor 6 exhibits antiproliferative activity on different tumor cell lines. Topoisomerase II inhibitor 6 blocks the cell cycle of CCRF-CEM in the G2 phase and induces DNA DSB. Topoisomerase II inhibitor 6 has the potential for the research of cancer diseases [1].

C19H18N4O2

334.37

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years