Pyributicarb 是氨基甲酸酯型除草剂，能够有效激活CYP3A4基因及人类孕烷 X 受体。

Pyributicarb is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR).

Pyributicarb was found to increase the CYP3A4 reporter activity at 0.1 to 1 microM more strongly than typical CYP3A4 inducer rifampicin.?Expression of hPXR-siRNA clearly diminished the pyributicarb-stimulated CYP3A4 reporter activity in 3-1-10 cells and decreased the endogenous CYP3A4 mRNA levels in HepG2 cells.?Pyributicarb caused enhancement of CYP3A4-derived reporter activity in mouse livers introduced with hPXR by adenovirus[1].

88678-67-5

C18H22N2O2S

330.45

稗草畏;TSH-888;Pyributicarb

DMSO:100 mg/mL (302.63 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years