PFM03 是MRE11 核酸内切酶的抑制剂。PFM03 通过非同源末端连接 (NHEJ) 调控 DNA 双链断裂修复 (DSBR)。

PFM03 is a MRE11 Endonuclease inhibitor. PFM03 regulates DNA double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) [1].

PFM03 (50-400 μM; 30 min) specifically inhibits MRE11 endonuclease activity [1]. PFM03 (100 μM; 30 min) causes normal DSB repair in G2 (CENPF + ) cells [1]. PFM03 (50 μM; 8 h) enhances NHEJ usage but reduces homologous recombination (HR) in cells [1].

1558598-48-3

C14H15NO2S2

293.4

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years