iRucaparib-AP6, a non-trapping PARP1 degrader, blocks both the catalytic activity and scaffolding effects of PARP1. iRucaparib-AP6 is a highly efficient and specific PARP1 degrader based on Rucaparib by using the PROTAC approach.

iRucaparib-AP6 (0-10 μM; 24 hours) decreases PARP-1 level in a dose dependent manner, exhibits a half-maximal degrading concentration (DC50) of 82?nM (Dmax?=?92%).

2410557-00-3

C46H55FN6O11

886.96

iRucaparib-AP6

DMSO:50 mg/mL (56.37 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years