PFM39, a Mirin analog, is a potent and selective MRE11 exonuclease inhibitor. PFM39 inhibits phosphate rotation for dsDNA exonuclease activity. PFM39 does not inhibits TmMre11 or human MRE11/MRN endonuclease activity.

PFM39 (100 μM) treatment impairs G2-phase double-strand break (DSB) repair in 1BR3-hTERT fibrolasts following ionizing irradiation (IR)[1]. PFM39 (50 μM) inhibits homologous recombination (HR) without significantly increasing NHEJ[1].

1310744-67-2

C10H9N3OS

219.26

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years