(Arg)9 TFA 是一种可渗透细胞的多肽,在谷氨酸模型实验模型中保护神经(IC50:0.78 μM)。
产品描述
(Arg)9 TFA (Nona-L-arginine TFA) is a cell-penetrating peptide. (Arg)9 TFA (Nona-L-arginine TFA) exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model.
体内活性
(Arg)9) (D-isoform) is neuroprotective in rat stroke models. (Arg)9) is highly neuroprotective, with efficacy increasing with increasing arginine content. It has the capacity to reduce glutamic acid-induced neuronal calcium influx and requires heparan sulfate preotoglycan-mediated endocytosis to induce a neuroprotective effect[2]. (Arg)9) (D-isoform) administered intravenously at a dose of 1000 nmol/kg 30 min after permanent middle cerebral artery occlusion (MCAO) reduces infarct volume[3].
Cas No.
2283335-13-5
分子式
C56H111F3N36O12
分子量
1537.739
别名
Nona-L-arginine (TFA);Peptide R9 (TFA);(Arg)9 TFA
储存和溶解度
H2O:10 mM
DMSO:Insoluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years