XE 991 dihydrochloride 是有效的Kv7 (KCNQ)通道阻滞剂，抑制Kv7.1 (KCNQ1)，Kv7.2 (KCNQ2)，Kv7.2 + Kv7.3 (KCNQ3)通道以及M-current，IC50分别为 0.75 μM、0.71 μM、0.6 μM、0.98 μM。

XE 991 dihydrochloride is a Kv7 (KCNQ) channel blocker. XE 991 dihydrochloride potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current (IC50s: 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively).

122955-13-9

C26H22Cl2N2O

449.37

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years