Quinacrine is a compound with multiple actions that is commonly used as an anti-protozoal agent. It has also been shown to be a highly potent autophagy inhibitor, although the dose required to achieve this effect is considerably cytotoxic (LD50 = 2.5 μM). Quinacrine analog 34 is a derivative of quinacrine that was designed with an improved cell viability profile (LD50 = 27 μM) to inhibit autophagy. At a minimum concentration of 0.5 μM, this compound has been shown to increase the protein levels of the autophagy biomarker LC3-II and to induce lysosome deacidification.

1411646-44-0

C20H27ClN4

358.91

DMSO:10 mg/mL
DMSO:PBS (pH 7.2) (1:1):0.5 mg/mL
Ethanol:5 mg/mL
DMF:10 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years