HDAC8-IN-3 (compound P19) 是一种有效的HDAC8抑制剂，其IC50值为 9.3 μM，可产生热稳定性。HDAC8-IN-3 具有细胞毒性并诱导白血病细胞系凋亡。

HDAC8-IN-3 (compound P19) is a potent HDAC8 inhibitor with IC 50 value of 9.3 μM and produces thermal stabilization. HDAC8-IN-3 has cytotoxicity and induces apoptosis in leukemic cell lines [1].

HDAC8-IN-3 (compound P19) (5-200 μM, 48 hours; HEK293T cells) has cytotoxicity in leukemic cell lines [1]. HDAC8-IN-3 (compound P19) (50 μM) inhibits glucose transporter 1 (GLUT1)-mediated glucose transport by down-regulating GLUT1 expression (IC 50 = 28.2 μM) [1]. HDAC8-IN-3 (compound P19) (79.9 μM; 24 hours) can induce apoptotic death in the CEM cell line [1]. Cell Cytotoxicity Assay [1] Cell Line: K562, KCL22 and CEM leukemia cells. Concentration: 50 μM Incubation Time: 48 hours Result: Inhibited with IC 50 values of 79.9, 85.4 and 43.2 μM for CEM, K562 and KCL22 cells, respectively. Apoptosis Analysis [1] Cell Line: CEM cells Concentration: 79.9 μM Incubation Time: 24 hours Result: The percentage of apoptotic cells was recorded as 60.97%.

2432825-93-7

C18H12N4O3S2

396.44

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years