HDAC8/BRPF1-IN-1 (Compound 23a) 是一种HDAC8和BRPF1的双抑制剂，对人 HDAC8 的IC50为 443 nM，对人 BRPF1 的Kd为 67 nM 。 HDAC8/BRPF1-IN-1 对 HDAC1 和 6 的体外活性较低。

HDAC8/BRPF1-IN-1 (Compound 23a) is a dual inhibitor of HDAC8 and BRPF1 with an IC 50 of 443 nM against human HDAC8 and a K d of 67 nM against human BRPF1. HDAC8/BRPF1-IN-1 shows low in vitro activity against HDAC1 and 6 [1].

HDAC8/BRPF1-IN-1 (Compound 23a) (4-100 μM; 24 h) shows antiproliferative activity against acute myeloid leukemia cells [1]. Cell Proliferation Assay [1] Cell Line: Acute myeloid leukemia cells THP-1 and HL60 Concentration: 4, 20 and 100 μM Incubation Time: 24 h Result: Inhibited THP-1 and HL60 cells growth.

2484255-85-6

C19H19N3O6S

417.44

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years