JNJ-37822681 是一种新型的、高选择性的多巴胺 D2 受体拮抗剂,其特点是与多巴胺 D2 受体的快速解离速率。
产品描述
JNJ-37822681 is a novel, highly selective dopamine D2 receptor antagonist characterized by a rapid dissociation rate from the dopamine D2 receptor.
体内活性
JNJ-37822681 occupied D2 receptors in rat brain at relatively low doses (ED50 = 0.39 mg/kg) and was effective in animal models of psychosis (e.g., inhibition of apomorphine-induced stereotypy or D-amphetamine/phencyclidine-induced hyperlocomotion)[4].
Cas No.
935776-74-2
分子式
C17H17F5N4
分子量
372.34
别名
JNJ 37822681;JNJ37822681
储存和溶解度
DMSO:55 mg/ml (147.71 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years