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SP187
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SP187图片
CAS NO:615253-61-7
包装:10 mg
市场价:12806元

产品名称
UV4
MON-DNJ
产品介绍

产品描述

SP187 is a host-targeted iminosugar. It also has activity against filovirus infections in vitro and in vivo.

体外活性

Antiviral activity for SP187 is observed with IC50 of 29.97 and 47.72 μM for EBOV and MARV, respectively [1].

体内活性

The efficacy of SP187 (UV-4) is first assessed using a mouse model of EBOV infection. In this study, C57Bl/6 mice are administered 10 or 100 mg/kg of SP187 or UV-5 via oral gavage or IP injection. Dosing started ~1h before infection with ~1000 pfu of mouse-adapted EBOV and is repeated BID for 10 days at approximately 12-hour intervals for UV-5 or TID at approximately 8-hour intervals for SP187. The selected doses and schedules are based on tolerability studies in na?ve mice [1].

Cas No.

615253-61-7

分子式

C16H33NO5

分子量

319.44

别名

UV4;MON-DNJ

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years