Pyridostatin Trihydrochloride 是一种 G-四链体稳定剂，Kd 为 490 nM。

Pyridostatin hydrochloride is a G-quadruplexe stabilizer, with a Kd of 490 nM.

Pyridostatin hydrochloride is a G-quadruplexe stabilizer, with a Kd of 490 nM. Pyridostatin (PDS) shows neurotoxic activity against primary cortical neurons at 0.01-5 μM, causes DNA double-strand breaks (DSBs) at 1 μM, downregulates BRCA1 in neurons at 1, 2 or 5 μM. Pyridostatin interacts with G-quadruplex motifs in SRC and alters mRNA levels of damaged genes

Cells are plated at equal confluence and either untreated or treated with 2 μM Pyridostatin continually for 72 h. Cells from individual plates are trypsinized and counted in a Coultercounter. Graphs represent total cell numbers at each time interval and error bars represent S.E.M. Data represent three independent experiments.

T4457

C31H35Cl3N8O5

706.02

RR-82 Trihydrochloride;Pyridostatin Trihydrochloride(free base 1085412-37-8 )

DMSO:10mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years