T2AA 是一种增殖细胞核抗原 (PCNA) 抑制剂，对 PCNA/PIP-box 肽相互作用的 IC50 为 1 μM。 T2AA 通过停止 DNA 复制叉和抑制 PCNA 与 DNA 聚合酶 δ 的相互作用来引起 DNA 复制压力并抑制癌细胞生长。

T2AA is an inhibitor of proliferating cell nuclear antigen (PCNA) with IC50 of 1 μM for PCNA/PIP-box peptide interaction. T2AA suppresses cancer cell growth and causes DNA replication stress by stalling DNA replication forks and inhibiting PCNA interaction with DNA polymerase δ.

1380782-27-3

C15H15I2NO3

511.09

4-[4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy]phenol

DMSO:8 mg/mL (15.7 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years