Tunicamycin 是同源核苷抗生素的混合物，可抑制 N-连接糖基化并阻断 GlcNAc 磷酸转移酶 (GPT)。 衣霉素抑制革兰氏阳性菌、酵母菌、真菌和病毒，并具有抗癌活性。

Tunicamycin is a mixture of homologous nucleoside antibiotic that inhibits N-linked glycosylation and blocks GlcNAc phosphotransferase (GPT). Tunicamycin inhibits gram-positive bacteria, yeasts, fungi, and viruses and has anti-cancer activity.

In CD44+/CD24- and original MCF7 cells, Tunicamycin (2 μg/mL; 24 hours; CD44+/CD24- and original MCF7 cells) treatment increases the spliced XBP-1, ATF6 nuclear translocation level and CHOP protein expression. Inhibited invasion, increased cell death, suppressed proliferation and reduced migration in the CD44+/CD24- and CD44+/CD24- rich MCF7 cell culture [1].

In the CD133+/- MHCC97L cells xenograft model (BALB/c (nu/nu) mice), Tunicamycin (0.1 mg/kg or 0.5 mg/kg) treatment dramatically suppresses tumor growth [2].

11089-65-9

C30H46N4O16

718.71

DMSO:40 mg/mL,Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years