SARS-CoV-2-IN-1 is a potent inhibitor of Mpro(SARS-CoV-2 Mpro, SARS-CoV Mpro and MERS-CoV Mpro with IC50s of 0.67, 0.90 and 0.58 μM, respectively).

SARS-CoV-2-IN-1 inhibits RNA replication with an EC50 of 1.75 μM in a SARS-CoV replicon. In human Calu3 cells infected with the novel coronavirus, SARS-CoV-2, SARS-CoV-2-IN1(EC50 of 4-5 μM).

SARS-CoV-2-IN-1 shows the Cmax is 126.2 ng/mL. The mean residence time for SARS-CoV-2-IN-1 is extended to 2.7 hours and the plasma half-life in CD-1 mice is 1.8 hour.

2412965-59-2

C31H39N5O7

593.67

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years