A 1120 是一种高亲和力的视黄醇结合蛋白 4 的拮抗剂(Ki:8.3 nM)。它能够破坏 RBP4 与其结合体转甲状腺素之间的相互作用。

A 1120 is a nonretinoid retinol-binding protein 4 (RBP4) antagonist (Ki: 8.3 nM), which disrupts the interaction between RBP4 and its binding partner transthyretin.

The IC50 of A 1120 is 66 nM on mouse RBP4 and 90 nM on human RBP4 [1].

1152782-19-8

C20H19F3N2O3

392.37

DMSO:95 mg/mL (242.12 mM,Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years