Dithranol 是蒽醌衍生物，可破坏线粒体功能和结构，用于治疗皮肤病。

Anthralin is an anthracene derivative that disrupts MITOCHONDRIA function and structure and is used for the treatment of DERMATOSES, especially PSORIASIS. It may cause FOLLICULITIS.

THP-1 and HEK293 cells are transiently transfected using DEAE-dextran and Polyfect reagent, respectively. Plasmids transfected contain genes coding for the NF-κB-dependent pELAM-luc luciferase reporter, TLR2, TLR4, CD14, and MD2. Cells (5×105 THP-1 or 1×105 HEK293) are added to 12-well plates, washed after 18 h, and stimulated for 5 h. Cells are then lysed with reporter lysis buffer as directed, and lysates are analyzed for luminescence using Promega luciferase substrate and a Monolight 3010 luminometer.

1143-38-0

C14H10O3

226.23

蒽林;Anthralin;cignoline;1,8,9-trihydroxyanthracene

DMSO:10 mM
Chloroform:41 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years