FluorofenIDOne 是 AMR69 的类似物，抗纤维化活性与AMR69相同，但FluorofenIDOne的毒性更低，半衰期长。它部分通过 PI3K/Akt 信号通路抑制 NADPH 氧化酶和细胞外基质 (ECM) 的沉积，能够减少肾间质纤维化的发生。

Fluorofenidone attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway. Fluorofenidone is an analogue of AMR69. Which displays equivalent lower toxicity, antifibrotic activity, and longer half-life.

848353-85-5

C12H10FNO

203.21

AKF-PD

DMSO:139 mg/mL (684.02 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years