Integrase-LEDGF/p75 allosteric inhibitor 1 (Compound 31h) 是一种具有口服活性的Integrase-LEDGF/p75 (IN-LEDGF/p75)变构抑制剂。Integrase-LEDGF/p75 allosteric inhibitor 1 抑制 HIV-1 DNA 整合，具有抗病毒活性，对 HIV-1重组分子克隆 NL432 的EC50为 3.9 nM。

Integrase-LEDGF/p75 allosteric inhibitor 1 (Compound 31h) is an orally active integrase-LEDGF/p75 (IN-LEDGF/p75) allosteric inhibitor. Integrase-LEDGF/p75 allosteric inhibitor 1 inhibits HIV-1 DNA integration and shows antiviral activity with an EC 50 of 3.9 nM against HIV-1 recombinant molecular clone NL432 [1].

Integrase-LEDGF/p75 allosteric inhibitor 1 (Compound 31h) has moderate metabolic stability (HLM MS = 59%, RLM MS = 61%), exhibits good clearance (CLt = 6.99 mL/min/kg) and good bioavailability (F = 36%) in rats [1].

1431738-14-5

C33H41NO6S

579.75

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years