PDE4-IN-9 (Compound 5j) 是一种有效的PDE4抑制剂。在体外酶试验中，PDE4-IN-9 对 PDE4 的IC50值 (1.4 μM) 低于亲本咯利普兰 (2.0 μM)。PDE4-IN-9 在 LPS 诱导的哮喘/COPD 和败血症动物模型中也显示出良好的体内活性。

PDE4-IN-9 (Compound 5j) is a potent inhibitor of PDE4. PDE4-IN-9 exhibits lower IC 50 value (1.4 μM) against PDE4 than parent rolipram (2.0 μM) in in vitro enzyme assay. PDE4-IN-9 also displays good in vivo activity in animal models of asthma/COPD and sepsis induced by LPS [1].

2519450-32-7

C15H12N4O3S

328.35

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years