NS-3-008 HCl 是一种口服具有活性的G0s2转录抑制剂(IC50:2.25 μM)。它可用于慢性肾脏疾病的研究。

NS-3-008 HCl is a transcriptional G0/G1 switch 2 (G0s2) inhibitor( IC50 of 2.25 μM).

Administration of NS-3-008 inhibited the expression of G0s2 in healthy mice liver.?In contrast, administration of NS-3-008 did not affect the MBP in wild-type sham and 5/6Nx mice.?NS-3-008 as a novel G0s2 inhibitor and showed that administration of this inhibitor ameliorated renal dysfunction in wild-type 5/6Nx mice.

1172854-54-4

C14H24ClN3

269.82

NS-3-008 HCl

DMSO:120 mg/ml(444.76 mM),Need ultrasonic
H2O:125 mg/mL (463.29 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years