S 38093 HCl 是一种新型的脑渗透性 H3 受体拮抗剂/反向激动剂。

S 38093 is a novel brain-penetrant antagonist/inverse agonist of H3 receptors.

PI3K inhibition by LY294002 is determined in a radiometric assay using purified, recombinant enzymes with 1 μM ATP. The kinase reaction is carried out for 1 hour at room temperature (24oC) and is terminated by addition of PBS. IC50 values are subsequently determined using a sigmoidal dose-response curve fit (variable slope). CK2 and GSK3β (glycogen synthase kinase 3β) inhibition are established by kinase selectivity screening. LY294002 is tested against the Upstate panel of kinases in 10 μM ATP.[4]

1222097-72-4

C17H25ClN2O2

324.85

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years