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Suberoyl bis-hydroxamic acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Suberoyl bis-hydroxamic acid图片
CAS NO:38937-66-5
包装与价格:
包装价格(元)
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Suberohydroxamic Acid
软木肟酸
SBHA
产品介绍
SBHA 是一种竞争性且可透过细胞的HDAC1和HDAC3抑制剂,ID50值分别为 0.25 μM 和 0.30 μM。它使肿瘤细胞易于凋亡并促进线粒体凋亡途径,可研究甲状腺髓样癌。

产品描述

SBHA (suberohydroxamic acid) is a Histone deacetylase (HDAC) inhibitor. HDAC is required for transcriptional modulation, cell cycle regulation and development. It is an enzyme that deacetylates lysine residues on the N-terminal of the core histones.

体外活性

In MEL cells, SBHA leads to the accumulation of acetylated H4, indicating the hydroxamic acid groups are involved in increasing potency and inhibition of HDAC activity. In Jurkat cells, SHBA inhibits the HDAC1 and HDAC3 activities with IC50 value of 0.25 and 0.3 μm respectively.

Cas No.

38937-66-5

分子式

C8H16N2O4

分子量

204.226

别名

Suberohydroxamic acid;软木肟酸;SBHA

储存和溶解度

DMSO:49 mg/mL (239.93 mM),Need ultrasonic
H2O:8.16 mg/mL (40 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years