A 425619 是一种有效的 TRPV1 拮抗剂。

A 425619 is a potent TRPV1 antagonist

systemic administration of the TRPV1 antagonist, A-425619, reversed the decrease in digging behavior induced by CFA injection, further confirming the role of TRPV1, expressed by knee neurons, in acute inflammatory joint pain.

581809-67-8

C18H14F3N3O

345.3252

1-(4-(TRIFLUOROMETHYL)BENZYL)-3-(ISOQUINOLIN-5-YL)UREA

DMSO:34.5 mg/mL (100 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years