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POL1-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
POL1-IN-1图片
CAS NO:1822358-25-7
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议

产品名称
Compound 3A
产品介绍
POL1-IN-1 是一种RNA聚合酶 1 POL1抑制剂,IC50值低于 0.5 uM。 它能有效抑制A375恶性黑色素瘤细胞系中RNA聚合酶I的转录。

产品描述

Compound 3A can effectively inhibit the transcription of RNA polymerase I in the A375 malignant melanoma cell line but has no effect on polymerase II.

体内活性

Corynoxine promotes the formation of autophagosomes in the fat bodies of Drosophila. By inducing autophagy, Corynoxine promotes the clearance of wild-type and A53T α-syn in inducible PC12 cells. Corynoxine induces autophagy through the Akt/mTOR pathway as evidenced by the reduction in the levels of phospho-Akt, phospho-mTOR and phospho-p70 S6 Kinase [1]. Corynoxine significantly decreased locomotor activity after oral administration to mice [2].

Cas No.

1822358-25-7

分子式

C21H20N6

分子量

356.433

别名

Compound 3A

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years