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Bedaquiline
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bedaquiline图片
CAS NO:843663-66-1
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
TMC207
贝达喹啉
R207910
产品介绍
Bedaquiline是一种二芳基喹啉药物,能同时靶向 c-亚基和 ε-亚基,抑制结核分枝杆菌 (Mtb) F1FO-ATP合酶。它具有解偶联活性和有用于耐多药结核病的潜力。

产品描述

Bedaquiline(TMC207; R207910) is an anti-tuberculosis drug which selectively inhibit the mycobacterial energy metabolism i.e. ATP synthesis and found to be effective against all states of Mycobacterium tuberculosis.

体外活性

Bedaquiline inhibits the growth of TDR M. tuberculosis strains, with MIC values ranging from 0.125 to 0.5 mg/L[1]. Among slowly growing mycobacteria (SGM), bedaquiline exhibits the highest activity against Mycobacterium avium with MIC50 and MIC90 values of 0.03 and 16 mg/L, respectively. Among rapidly growing mycobacteria (RGM), Mycobacterium abscessus subsp. abscessus (M. abscessus) and Mycobacterium abscessus subsp. massiliense (M. massiliense) seem more susceptible to bedaquiline than Mycobacterium fortuitum, with MIC50 and MIC90 values of 0.13 and >16 mg/L, respectively, for both species. Bedaquiline also shows moderate in vitro activity against NTM species[2]. Bedaquiline has an excellent in vitro activity against Mycobacterium tuberculosis, including multidrug resistant M tuberculosis[3].

Cas No.

843663-66-1

分子式

C32H31BrN2O2

分子量

555.516

别名

TMC207;贝达喹啉;R207910

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years