Ticarcillin sodium 主要用于抗革兰氏阴性菌, 也能用于研究嗜麦芽感染。
产品描述
Ticarcillin is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria.
体外活性
MICs of Ticarcillin (64 mg/mL) for 90% of all beta-lactamase-positive strains are reduced to 2 mg/mL, with the addition of clavulanate. MICs of Ticarcillin for 90% of all beta-lactamase-negative strains are 4 mg/mL. 93.4% of the beta-lactamase-producing strains are susceptible to Ticarcillin at less than or equal to 64 mg/mL. [1] Ticarcillin/potassium clavulanate is light stable and resistant to inactivation by β-lactamase. Ticarcillin/potassium clavulanate is more economical than carbenicillin and cefotaxime to eliminate Agrobacterium tumefaciens in plant transformation. [2]
体内活性
The mean elimination half-life of Ticarcillin (120 mg/kg) in serum is 70.8 minutes in the control subjects and 53.1 minutes in the patients with cystic fibrosis. The total body clearance of Ticarcillin is significantly higher in cystic fibrosis patients (65.6 mL/min/m2 versus 46.2 mL/min/m2 in control subjects). The nonrenal clearance of ticarcillin is also significantly higher in patients with cystic fibrosis (24.8 mL/min/m2 versus 13.3 mL/min/m2 for the control group). [3] Ticarcillin/clavulanate (3.1 g, given iv every 4-6 hours) results in clinical success rate of 80.3% and clinical failure rate of 19.7% in the treatment of complicated skin and skin-structure infections. The overall rate of eradication is 83.7% in the Ticarcillin/clavulanate treatment group in the microbiologically evaluable population. [4] Ticarcillin/clavulanate results in cure rates of 79% at the time of final assessment for the treatment of intra-abdominal infections in pediatric and adult patients. [5]
Cas No.
29457-07-6
分子式
C15H16N2O6S2·2Na
分子量
430.41
别名
Aerugipen hydrate;Ticarpen hydrate;Monapen;AB 2288;BRL 2288;替卡西林单钠盐单水合物
储存和溶解度
H2O:79 mg/mL (183.5 mM)
DMSO:80 mg/mL (185.9 mM)
Ethanol:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years