您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Oxolinic acid
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Oxolinic acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:14698-29-4
包装与价格:
包装价格(元)
500 mg电议
1 g电议

产品名称
恶喹酸
Nidantin
Dioxacin
Urinox
Emyrenil
NSC 110364
产品介绍
Oxolinic acid 是一种抗生素,对革兰氏阴性菌和革兰氏阳性菌均有效,可研究急性和慢性尿路感染。它是一种 DNA/RNA 合成抑制剂,也是一种多巴胺摄取抑制剂,能刺激小鼠的活跃过度。

产品描述

Oxolinic acid is a synthetic antimicrobial related to NALIDIXIC ACID and used in URINARY TRACT INFECTIONS.

体外活性

Oxolinic acid, a quinolone antibacterial agent, inhibits reversibly the ATP-dependent replicative DNA synthesis in permeable cell systems as well as in cellophane disk lysates[4]. It also inhibits bacterial DNA gyrase but not eukaryotic topoisomerases, reversibly binding gyrase subunit A in gyrase-DNA complexes, blocking supercoiling activity and inhibiting DNA synthesis at 0.5-5 μg/ml[5][6][7].

体内活性

The antimicrobial agent oxolinic acid, injected i.p. in mice, induces a dose dependent increase in locomotor activity. the stimulant locomotor effect of oxolinic acid depends on the blockade of the neuronal dopamine uptake complex[2].

Cas No.

14698-29-4

分子式

C13H11NO5

分子量

261.233

别名

恶喹酸;Nidantin;Dioxacin;Urinox;Emyrenil;NSC 110364

储存和溶解度

DMSO:2.5 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years