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GV-58
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GV-58图片
CAS NO:1402821-41-3
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
GV-58 是选择性 N 型和 P/Q 型 Ca2+ 通道激动剂,EC50值分别为7.21和8.81uM。它对 CDK 激酶活性的抑制作用减少了 20 倍。

产品描述

GV-58 is a selective N- and P/Q-type Ca2+ channels agonist (EC50: 7.21/8.81 uM for N-type/P-Q-type Ca2+ channel). The inhibitory of GV-58 is 20-fold fewer for CDK kinases activity.

体外活性

In comparison with the parent molecule, (R)-roscovitine, GV-58 has a 20-fold less potent cyclin-dependent kinase antagonist effect, a 3- to 4-fold more potent Ca2+ channel agonist effect, and 4-fold higher efficacy as a Ca2+ channel agonist. GV-58 had no agonist activity (up to 100 μm) on the L-type α-subunit we tested (Cav1.3).

Cas No.

1402821-41-3

分子式

C18H26N6OS

分子量

374.5

储存和溶解度

DMSO:90 mg/mL (240.32 mM),Need ultrasonic
Methanol:55 mg/mL (146.86 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years