您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > BRD7552
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
BRD7552
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BRD7552图片
CAS NO:1137359-47-7
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
BRD7552 是PDX1转录因子诱导剂,它能够上调人类原代胰岛和导管细胞中 PDX1 的表达,诱导 PDX1 启动子的表观遗传变化与转录激活一致,提高胰岛素表达。其中 PDX1 是参与胰腺发育和β细胞功能的关键转录因子。

产品描述

BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells.

体外活性

BRD7552 upregulates PDX1 expression in both primary human islets and ductal cells, and induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. BRD7552 increases PDX1 mRNA levels by 2- to 4-fold, with a maximal effect at 5 μM and the expression of MAFA. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells. Treatment of PANC-1 cells with BRD7552 causes a dose-dependent increase in insulin mRNA expression. [1]

Cas No.

1137359-47-7

分子式

C33H33N3O15

分子量

711.633

储存和溶解度

Ethanol:93 mg/mL (130.7 mM)
DMSO:93 mg/mL (130.7 mM)
H2O:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years