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DPC-681
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DPC-681图片
CAS NO:284661-68-3
包装与价格:
包装价格(元)
10 mg电议
25 mg电议
50 mg电议

产品名称
DPH-153893
产品介绍

产品描述

DPC-681 is a potent and selective HIV protease inhibitor (IC90s: 4 to 40 nM for wild-type HIV-1).

体外活性

DPC 681 displays no loss in potency toward recombinant mutant HIVs with the D30N mutation and a fivefold or smaller loss in potency toward mutant variants with three to five amino acid substitutions. When all of the HIV-1 strains tested are considered, the average concentrations required for 90% inhibition of replication were 7.3 ± 3.4 for DPC 681.

体内活性

The total body clearance (CL) of DPC 681 in dogs was high (1.8 liters/h/kg) equaling hepatic blood flow for this species (1.8 liters/h/kg). The Cmax increased ninefold between the 10- and 30-mg/kg DPC 681 dose groups. Bioavailability also increased between the 10- and 30-mg/kg dose groups (18.3 and 78.1%, respectively), after oral dosing. These data show that hepatic extraction (first-pass effect) can be saturated in the dog.

Cas No.

284661-68-3

分子式

C35H48FN5O5S

分子量

669.85

别名

DPH-153893

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years