NF-κΒ activator 2 是口服有效的NF-?B激活剂，EC50为 1.58 μM。它通过增加 NF-Κb 的表达和激活来诱导 SOD2。它具有用于研究肌萎缩性侧索硬化症的价值。

NF-κΒ activator 2 is a potent and orally active NF-κB activator, with an EC 50 of 1.58 μM. NF-κΒ activator 2 induces SOD 2 through increasing NF-κB expression and activation. NF-κΒ activator 2 can be used for the research of amyotrophic lateral sclerosis (ALS) [1] .

NF-κB activator 2 (Compound 61) (1 μM, 6 hr) induces SOD 2 mRNA expression in SH-SY5Y neuroblastoma cells [1]. SOD2 is a highly inducible SOD that performs in concurrence with SOD1 to detoxify ROS. Induction of SOD2 can be obtained through the activation of NF-?Bs.

NF-κΒ activator 2 (1 mg/kg; i.v.) exhibits a suitable half-life (0.96 h) in mice [1]. NF-κΒ activator 2 (5 mg/kg; p.o.) exhibits a comparable half-life (2.86 h), oral bioavailability (15.6%), and C max (92 ng/mL) [1].

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C16H11FN2O3

298.273

DMSO:250 mg/mL (838.17 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years