Sulfosuccinimidyl oleate sodium 是一种长链脂肪酸。它可以抑制脂肪酸转运到细胞中。它具有抗炎作用。

Sulfosuccinimidyl oleate sodium is a long-chain fatty acid that inhibits the transport of fatty acids to cells. Sulfosuccinimidyl oleate sodium is an effective, irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate sodium binds to CD36 receptors on the surface of microglia.

Sulfosuccinimidyl oleate (50 μM, 24 hours) co-treatment significantly reduces the LPS+IFNγ-induced expression of NOS2 and COX-2 in BV2 cells. Western blot analysis reveals a significant LPS/IFNγ-induced upregulation in the phosphorylated form of the p38, which is prevented by co-treatment with Sulfosuccinimidyl oleate (50 μM, 24 hours)[1].

In male BALB/cABom mice with pMCAo model, Sulfosuccinimidyl oleate (50 mg/kg; administered once by single oral gavage) significantly reduces the cortical ischemic infarct size compared to vehicle-treated controls. In addition, Sulfosuccinimidyl oleate(50 mg/kg) is suitable to see a beneficial effect after stroke[1].

1212012-37-7

C22H36NNaO7S

481.58

Sulfo-N-succinimidyl oleate sodium

DMSO:60 mg/mL (124.59 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years