ALK5-IN-9 (Compound 8h) 是一种有效并具有口服活性的TGFβRI(ALK5) 抑制剂。ALK5-IN-9 抑制 ALK5 自磷酸化和 NIH3T3 细胞活性，IC50值分别为 25 nM 和 74.6 nM。ALK5-IN-9 还显示出良好的药代动力学特征并改善了 hERG 抑制。ALK5-IN-9具有研究癌症疾病的潜力。

ALK5-IN-9 (Compound 8h) is a potent and orally active inhibitor of TGFβRI ( ALK5 ). ALK5-IN-9 inhibits ALK5 autophosphorylation and NIH3T3 cell activity with IC 50 values of 25 nM and 74.6 nM, respectively. ALK5-IN-9 also shows favorable pharmacokinetic profile and ameliorated hERG inhibition. ALK5-IN-9 has the potential for the research of cancer disease [1].

2489611-06-3

C29H35F3N6O3

572.62

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years