OF-1 是溴结构域的一种抑制剂，其对TRIM24 和BRPF1B 的IC50值分别为270 nM 和1.2 μM。

OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain.

As a chemical probe for BRPF bromodomains, OF-1 increases thermal stability in the cellular thermal shift assay of full length BRPF1B at 1 μM and also demonstrates accelerated FRAP recovery at 5 μM in the BRPF2 FRAP assay. In addition, OF-1 shows modest general cytotoxicity. [1]

919973-83-4

C17H18BrN3O4S

440.31

DMSO:8.8 mg/mL (20 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years