4-hydroperoxy Cyclophosphamide (4-OOH-CY) is the active metabolite form of the prodrug Cyclophosphamide. 4-OOH-CY crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS).[1] Formulations containing the prodrug Cyclophosphamide are used to treat lymphomas and autoimmune disorders.[2],[3]

39800-16-3

C7H15Cl2N2O4P

293.08

4-hydroperoxy Cyclophosphamide;4-OOH-CY

Dichloromethane:Soluble
DMSO:30 mg/mL
Chloroform:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years