KRN5 是一种有效的 NFAT5 的抑制剂，IC50 为 750 nM，可用于慢性关节炎的研究。

KRN5 is an effective inhibitor of NFAT5 with an IC50 of 750 nM and can be used in studies about chronic arthritis.

KRN5 (1 μM) inhibits the expressions of NFAT5, IL-6,MCP-1, and GM-CSF in RAW264.7 macrophages stimulated with LPS[1].

In DBA/1Jmice immunized with bovine type II collagen, KRN5 (15 and 60 mg/kg; oral) dose-dependently mitigates arthritis severity. KRN5 significantly decreases the concentration of serum anti-type II collagen IgG in the sera. KRN5 lowers TNF-α and IL-6 production by LPS-stimulated splenocytes in mice[1].

1800465-47-7

C27H22FNO5

459.47

DMSO:5 mg/mL (10.9 mM),Need ultrasonicand warming and heat to 80°C
Powder: -20°C for 3 years
In solvent: -80°C for 2 years