PDE4B inhibitor is an inhibitor of phosphodiesterase 4B (PDE4B; IC50= 140 nM).1,2It is selective for PDE4B over a panel of 20 PDE isoforms and a panel of 39 CNS receptors at 10 μM but does inhibit the activity of PDE4C1, PDE3B, the serotonin (5-HT) receptor subtype 5-HT2C, and sigma-2 (σ2) receptors by greater than 50%.1PDE4B inhibitor (1 μM) decreases LPS- or Pam3Cys-induced production of TNF-α in mouse bone marrow-derived macrophages (BMDMs). It reduces cocaine self-administration and the progressive ratio breakpoint in mice when administered at a dose of 5 mg/kg.2

2410550-31-9

C17H11Cl2F2N3O

382.19

DMSO:30 mg/mL
DMF:30 mg/mL
DMSO:PBS (pH 7.2) (1:5):0.16 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years